Analysis of Matched Tumor and Normal Profiles Reveals Common Transcriptional and Epigenetic Signals Shared across Cancer Types

To identify the transcriptional regulatory changes that are most widespread in solid tumors, we performed a pan-cancer analysis using over 600 pairs of tumors and adjacent normal tissues profiled in The Cancer Genome Atlas (TCGA). Frequency of upregulation was calculated across mRNA expression level...

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Detalles Bibliográficos
Autores principales: Gross, Andrew M., Kreisberg, Jason F., Ideker, Trey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640835/
https://www.ncbi.nlm.nih.gov/pubmed/26555223
http://dx.doi.org/10.1371/journal.pone.0142618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640835/
https://www.ncbi.nlm.nih.gov/pubmed/26555223
http://dx.doi.org/10.1371/journal.pone.0142618

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