Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer

NKX2-1, encoding a homeobox transcription factor, is amplified in approximately 15% of non-small cell lung cancers (NSCLC), where it is thought to drive cancer cell proliferation and survival. However, its mechanism of action remains largely unknown. To identify relevant downstream transcriptional t...

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Detalles Bibliográficos
Autores principales: Clarke, Nicole, Biscocho, Jewison, Kwei, Kevin A., Davidson, Jean M., Sridhar, Sushmita, Gong, Xue, Pollack, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640868/
https://www.ncbi.nlm.nih.gov/pubmed/26556242
http://dx.doi.org/10.1371/journal.pone.0142061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640868/
https://www.ncbi.nlm.nih.gov/pubmed/26556242
http://dx.doi.org/10.1371/journal.pone.0142061

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