Cargando…

Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells

Acquired or de novo resistance to the selective estrogen receptor modulators tamoxifen and fulvestrant (ICI) is a major barrier to successful treatment of breast cancer. Gene expression patterns in tamoxifen resistant (TamR-MCF-7) cells were compared to their parental cells (MCF-7L) to identify an a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walter, William, Thomalla, Jennifer, Bruhn, Josh, Fagan, Dedra H., Zehowski, Cheryl, Yee, Douglas, Skildum, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641142/ https://www.ncbi.nlm.nih.gov/pubmed/26576332 http://dx.doi.org/10.1186/s40064-015-1444-2

Ejemplares similares

Functional Ablation of pRb Activates Cdk2 and Causes Antiestrogen Resistance in Human Breast Cancer Cells
por: Varma, Hemant, et al.
Publicado: (2007)

The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance
por: Suba, Zsuzsanna
Publicado: (2015)

ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer
por: Zhang, Jianbo, et al.
Publicado: (2017)

Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER(+) Breast Cancer
por: Servetto, Alberto, et al.
Publicado: (2021)

Increased expression of the HDAC9 gene is associated with antiestrogen resistance of breast cancers
por: Linares, Aurélien, et al.
Publicado: (2019)

The Role of Long Noncoding RNAs in Antiestrogen Resistance in Breast Cancer: An Overview and Update
por: Huang, Lan, et al.
Publicado: (2020)

Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor
por: Li, Ye, et al.
Publicado: (2021)

An empirical Bayes model for gene expression and methylation profiles in antiestrogen resistant breast cancer
por: Jeong, Jaesik, et al.
Publicado: (2010)

Antiestrogens: structure-activity relationships and use in breast cancer treatment
por: Traboulsi, T, et al.
Publicado: (2016)

Exosome-Mediated Transfer of Cancer Cell Resistance to Antiestrogen Drugs
por: Semina, Svetlana E., et al.
Publicado: (2018)

Resveratrol Sensitizes Tamoxifen in Antiestrogen-Resistant Breast Cancer Cells with Epithelial-Mesenchymal Transition Features
por: Shi, Xiao-Peng, et al.
Publicado: (2013)

ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer
por: Kalyuga, Maria, et al.
Publicado: (2012)

Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
por: Lee, Kyung-min, et al.
Publicado: (2020)

Estrogenic or antiestrogenic therapies for multiple myeloma?
por: Sola, Brigitte, et al.
Publicado: (2007)

Breast Cancer Antiestrogen Resistance 3 (BCAR3) – p130(Cas) Interactions Promote Adhesion Disassembly and Invasion in Breast Cancer Cells
por: Cross, Allison M., et al.
Publicado: (2016)

Response of Estrogen Receptor-Positive Breast Cancer Tumorspheres to Antiestrogen Treatments
por: Ao, Ada, et al.
Publicado: (2011)

Combination of Antiestrogens and Omega-3 Fatty Acids for Breast Cancer Prevention
por: Manni, Andrea, et al.
Publicado: (2015)

G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells
por: Corbet, Andrea K., et al.
Publicado: (2023)

The Landscape of PDK1 in Breast Cancer
por: Wang, Na, et al.
Publicado: (2022)

Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer
por: Zhou, Yamei, et al.
Publicado: (2007)

The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer
por: Schwartz, J. L., et al.
Publicado: (2011)

Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data
por: Zhang, Denan, et al.
Publicado: (2014)

Activation of the Her2/neu receptor leads to antiestrogen resistance, but acquired resistance is not caused by altered ErbB expression and activation
por: Larsen, SS, et al.
Publicado: (2000)

Breast Cancer Antiestrogen Resistance 3 (BCAR3) Promotes Cell Motility by Regulating Actin Cytoskeletal and Adhesion Remodeling in Invasive Breast Cancer Cells
por: Wilson, Ashley L., et al.
Publicado: (2013)

Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer
por: Larsen, Sarah L, et al.
Publicado: (2015)

OR11-02 Structural Determinants of Pure Antiestrogenic Activity
por: Vallet, Amandine, et al.
Publicado: (2023)

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells
por: Alam, Muhammad Wasi, et al.
Publicado: (2016)

The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells
por: Crone, Michael, et al.
Publicado: (2019)

Src Drives Growth of Antiestrogen Resistant Breast Cancer Cell Lines and Is a Marker for Reduced Benefit of Tamoxifen Treatment
por: Larsen, Sarah L., et al.
Publicado: (2015)

Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 Mediates Antiestrogen Resistance in Human Breast Cancer Cells
por: Pulliam, Nicholas, et al.
Publicado: (2019)

HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer
por: Sun, Xiaodan, et al.
Publicado: (2022)

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism
por: Sola, Brigitte, et al.
Publicado: (2013)

Immunohistochemical analysis of PDK1 expression in breast cancer
por: Arsenic, Ruza
Publicado: (2014)

A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses
por: Clusan, Léa, et al.
Publicado: (2021)

Reduced Expression of miR-200 Family Members Contributes to Antiestrogen Resistance in LY2 Human Breast Cancer Cells
por: Manavalan, Tissa T., et al.
Publicado: (2013)

Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand
por: El-Halawany, Ali M., et al.
Publicado: (2011)

Estrogenic/antiestrogenic activity of selected selective serotonin reuptake inhibitors
por: POP, ANCA, et al.
Publicado: (2015)

Gingival cell growth with antiresorptive treatment combined with corticosteroids or antiestrogen
por: Ekholm, Heidi M., et al.
Publicado: (2021)

Inhibition of Cancer Cell Proliferation and Metastasis by Insulin Receptor Downregulation
por: Zhang, Hua, et al.
Publicado: (2010)

An integrative analysis of cellular contexts, miRNAs and mRNAs reveals network clusters associated with antiestrogen-resistant breast cancer cells
por: Nam, Seungyoon, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1s0e1f8j545tlkk948ugp8hrmi