A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus

We have developed an antagonist to suppressor of cytokine signaling 1 (SOCS1), pJAK2(1001–1013), which corresponds to the activation loop of the Janus kinase JAK2, which is the binding site for the kinase inhibitory region (KIR) of SOCS1. Internalized pJAK2(1001–1013) inhibits SOCS1 and SOCS3. SOCS1...

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Detalles Bibliográficos
Autores principales: Ahmed, Chulbul M., Dabelic, Rea, Bedoya, Simone Kennedy, Larkin, Joseph, Johnson, Howard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641302/
https://www.ncbi.nlm.nih.gov/pubmed/26617608
http://dx.doi.org/10.3389/fimmu.2015.00574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641302/
https://www.ncbi.nlm.nih.gov/pubmed/26617608
http://dx.doi.org/10.3389/fimmu.2015.00574

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