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Two alternative pathways for generating transmissible prion disease de novo
INTRODUCTION: Previous studies established that prion disease with unique strain-specific phenotypes could be induced by in vitro-formed recombinant PrP (rPrP) fibrils with structures different from that of authentic prions, or PrP(Sc). To explain the etiology of prion diseases, new mechanism propos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641408/ https://www.ncbi.nlm.nih.gov/pubmed/26556038 http://dx.doi.org/10.1186/s40478-015-0248-5 |