A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates

By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as we...

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Detalles Bibliográficos
Autores principales: Shirani, Hamid, Linares, Mathieu, Sigurdson, Christina J, Lindgren, Mikael, Norman, Patrick, Nilsson, K Peter R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641461/
https://www.ncbi.nlm.nih.gov/pubmed/26388448
http://dx.doi.org/10.1002/chem.201502999
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author Shirani, Hamid
Linares, Mathieu
Sigurdson, Christina J
Lindgren, Mikael
Norman, Patrick
Nilsson, K Peter R
author_facet Shirani, Hamid
Linares, Mathieu
Sigurdson, Christina J
Lindgren, Mikael
Norman, Patrick
Nilsson, K Peter R
author_sort Shirani, Hamid
collection PubMed
description By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.
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spelling pubmed-46414612015-11-16 A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates Shirani, Hamid Linares, Mathieu Sigurdson, Christina J Lindgren, Mikael Norman, Patrick Nilsson, K Peter R Chemistry Communications By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections. WILEY-VCH Verlag 2015-10-19 2015-09-21 /pmc/articles/PMC4641461/ /pubmed/26388448 http://dx.doi.org/10.1002/chem.201502999 Text en © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. https://creativecommons.org/licenses/by/4.0/ © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Shirani, Hamid
Linares, Mathieu
Sigurdson, Christina J
Lindgren, Mikael
Norman, Patrick
Nilsson, K Peter R
A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
title A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
title_full A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
title_fullStr A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
title_full_unstemmed A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
title_short A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
title_sort palette of fluorescent thiophene-based ligands for the identification of protein aggregates
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641461/
https://www.ncbi.nlm.nih.gov/pubmed/26388448
http://dx.doi.org/10.1002/chem.201502999
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