Cargando…
A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as we...
Autores principales: | Shirani, Hamid, Linares, Mathieu, Sigurdson, Christina J, Lindgren, Mikael, Norman, Patrick, Nilsson, K Peter R |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641461/ https://www.ncbi.nlm.nih.gov/pubmed/26388448 http://dx.doi.org/10.1002/chem.201502999 |
Ejemplares similares
-
Deciphering the Electronic Transitions of Thiophene‐Based Donor‐Acceptor‐Donor Pentameric Ligands Utilized for Multimodal Fluorescence Microscopy of Protein Aggregates
por: Gustafsson, Camilla, et al.
Publicado: (2020) -
The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates
por: Klingstedt, Therése, et al.
Publicado: (2013) -
Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands
por: Magnusson, Karin, et al.
Publicado: (2014) -
Pentameric Thiophene-Based Ligands that Spectrally Discriminate Amyloid-β and Tau Aggregates Display Distinct Solvatochromism and Viscosity-Induced Spectral Shifts
por: Simon, Rozalyn A, et al.
Publicado: (2014) -
Thiophene‐Based Optical Ligands That Selectively Detect Aβ Pathology in Alzheimer's Disease
por: Klingstedt, Therése, et al.
Publicado: (2021)