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Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

Acetylation is frequently detected on mitochondrial enzymes, and the sirtuin deacetylase SIRT3 is thought to regulate metabolism by deacetylating mitochondrial proteins. However, the stoichiometry of acetylation has not been studied and is important for understanding whether SIRT3 regulates or suppr...

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Detalles Bibliográficos
Autores principales: Weinert, Brian T, Moustafa, Tarek, Iesmantavicius, Vytautas, Zechner, Rudolf, Choudhary, Chunaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641529/
https://www.ncbi.nlm.nih.gov/pubmed/26358839
http://dx.doi.org/10.15252/embj.201591271