Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies

[Image: see text] YopH tyrosine phosphatase, a virulence factor produced by pathogenic species of Yersinia, is an attractive drug target. In this work, three oxidovanadium(IV) complexes were assayed against recombinant YopH and showed strong inhibition of the enzyme in the nanomolar range. Molecular...

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Detalles Bibliográficos
Autores principales: Martins, Priscila G. A., Mori, Mattia, Chiaradia-Delatorre, Louise D., Menegatti, Angela C. O., Mascarello, Alessandra, Botta, Bruno, Benítez, Julio, Gambino, Dinorah, Terenzi, Hernán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641580/
https://www.ncbi.nlm.nih.gov/pubmed/26617957
http://dx.doi.org/10.1021/acsmedchemlett.5b00267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641580/
https://www.ncbi.nlm.nih.gov/pubmed/26617957
http://dx.doi.org/10.1021/acsmedchemlett.5b00267

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