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Mechanosensitive TRPM7 mediates shear stress and modulates osteogenic differentiation of mesenchymal stromal cells through Osterix pathway
Microenvironments that modulate fate commitments of mesenchymal stromal cells (MSCs) are composed of chemical and physical cues, but the latter ones are much less investigated. Here we demonstrate that intermittent fluid shear stress (IFSS), a potent and physiologically relevant mechanical stimulus,...
Autores principales: | Liu, Yi-Shiuan, Liu, Yu-An, Huang, Chin-Jing, Yen, Meng-Hua, Tseng, Chien-Tzu, Chien, Shu, Lee, Oscar K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642269/ https://www.ncbi.nlm.nih.gov/pubmed/26558702 http://dx.doi.org/10.1038/srep16522 |
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