Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

Enterocytes play an important role in drug absorption and metabolism. However, a widely used enterocyte model, Caco-2 cell, has difficulty in evaluating both drug absorption and metabolism because the expression levels of some drug absorption and metabolism-related genes in these cells differ largel...

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Detalles Bibliográficos
Autores principales: Ozawa, Tatsuya, Takayama, Kazuo, Okamoto, Ryota, Negoro, Ryosuke, Sakurai, Fuminori, Tachibana, Masashi, Kawabata, Kenji, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642303/
https://www.ncbi.nlm.nih.gov/pubmed/26559489
http://dx.doi.org/10.1038/srep16479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642303/
https://www.ncbi.nlm.nih.gov/pubmed/26559489
http://dx.doi.org/10.1038/srep16479

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