Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease

Alzheimer disease is a multifactorial pathology and the development of new multitarget neuroprotective drugs is promising and attractive. We synthesized a group of original compounds, which combine in one molecule γ-carboline fragment of dimebon and phenothiazine core of methylene blue (MB) linked b...

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Detalles Bibliográficos
Autores principales: Makhaeva, Galina F., Lushchekina, Sofya V., Boltneva, Natalia P., Sokolov, Vladimir B., Grigoriev, Vladimir V., Serebryakova, Olga G., Vikhareva, Ekaterina A., Aksinenko, Alexey Yu., Barreto, George E., Aliev, Gjumrakch, Bachurin, Sergey O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642525/
https://www.ncbi.nlm.nih.gov/pubmed/26281952
http://dx.doi.org/10.1038/srep13164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642525/
https://www.ncbi.nlm.nih.gov/pubmed/26281952
http://dx.doi.org/10.1038/srep13164

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