Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift

Mitochondrial DNA is prone to damage by various intrinsic as well as environmental stressors. DNA damage can in turn cause problems for replication, resulting in replication stalling and double-strand breaks, which are suspected to be the leading cause of pathological mtDNA rearrangements. In this s...

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Detalles Bibliográficos
Autores principales: Torregrosa-Muñumer, Rubén, Goffart, Steffi, Haikonen, Juha A., Pohjoismäki, Jaakko L. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642854/
https://www.ncbi.nlm.nih.gov/pubmed/26399294
http://dx.doi.org/10.1091/mbc.E15-06-0390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642854/
https://www.ncbi.nlm.nih.gov/pubmed/26399294
http://dx.doi.org/10.1091/mbc.E15-06-0390

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