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Identification of High-Impact cis-Regulatory Mutations Using Transcription Factor Specific Random Forest Models
Cancer genomes contain vast amounts of somatic mutations, many of which are passenger mutations not involved in oncogenesis. Whereas driver mutations in protein-coding genes can be distinguished from passenger mutations based on their recurrence, non-coding mutations are usually not recurrent at the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642938/ https://www.ncbi.nlm.nih.gov/pubmed/26562774 http://dx.doi.org/10.1371/journal.pcbi.1004590 |