Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

Alzheimer’s disease (AD) therapeutics based on the amyloid hypothesis have shown minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only one aspect of AD pathogenesis. Since neuroinflammation is thought to play an important role in AD, we hypothesized that cyt...

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Detalles Bibliográficos
Autores principales: Wood, Levi B., Winslow, Ashley R., Proctor, Elizabeth A., McGuone, Declan, Mordes, Daniel A., Frosch, Matthew P., Hyman, Bradley T., Lauffenburger, Douglas A., Haigis, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643219/
https://www.ncbi.nlm.nih.gov/pubmed/26564777
http://dx.doi.org/10.1038/srep16622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643219/
https://www.ncbi.nlm.nih.gov/pubmed/26564777
http://dx.doi.org/10.1038/srep16622

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