Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations

Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/−); Notch3(−/−) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Kofler, Natalie M., Cuervo, Henar, Uh, Minji K., Murtomäki, Aino, Kitajewski, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643246/
https://www.ncbi.nlm.nih.gov/pubmed/26563570
http://dx.doi.org/10.1038/srep16449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643246/
https://www.ncbi.nlm.nih.gov/pubmed/26563570
http://dx.doi.org/10.1038/srep16449

Ejemplares similares