Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells

The c-Myc protein is dysregulated in many human cancers and its function has not been fully elucitated yet. The c-Myc inhibitor Omomyc displays potent anticancer properties in animal models. It perturbs the c-Myc protein network, impairs c-Myc binding to the E-boxes, retaining transrepressive proper...

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Detalles Bibliográficos
Autores principales: Mongiardi, Maria Patrizia, Savino, Mauro, Bartoli, Laura, Beji, Sara, Nanni, Simona, Scagnoli, Fiorella, Falchetti, Maria Laura, Favia, Annarita, Farsetti, Antonella, Levi, Andrea, Nasi, Sergio, Illi, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643314/
https://www.ncbi.nlm.nih.gov/pubmed/26563484
http://dx.doi.org/10.1038/srep15494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643314/
https://www.ncbi.nlm.nih.gov/pubmed/26563484
http://dx.doi.org/10.1038/srep15494

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