Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis

The PP2A signaling axis regulates multiple oncogenic drivers of castration resistant prostate cancer (CRPC). We show that targeting the endogenous PP2A regulator, SET (I2PP2A), is a viable strategy to inhibit prostate cancers that are resistant to androgen deprivation therapy. Our data is corroborat...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Xiaoyong, Garcia, Consuelo, Fazli, Ladan, Gleave, Martin, Vitek, Michael P., Jansen, Marilyn, Christensen, Dale, Mulholland, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643319/
https://www.ncbi.nlm.nih.gov/pubmed/26563471
http://dx.doi.org/10.1038/srep15182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643319/
https://www.ncbi.nlm.nih.gov/pubmed/26563471
http://dx.doi.org/10.1038/srep15182

Ejemplares similares