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Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis

The PP2A signaling axis regulates multiple oncogenic drivers of castration resistant prostate cancer (CRPC). We show that targeting the endogenous PP2A regulator, SET (I2PP2A), is a viable strategy to inhibit prostate cancers that are resistant to androgen deprivation therapy. Our data is corroborat...

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Detalles Bibliográficos
Autores principales:	Hu, Xiaoyong, Garcia, Consuelo, Fazli, Ladan, Gleave, Martin, Vitek, Michael P., Jansen, Marilyn, Christensen, Dale, Mulholland, David J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643319/ https://www.ncbi.nlm.nih.gov/pubmed/26563471 http://dx.doi.org/10.1038/srep15182

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