Monogenic forms of childhood obesity due to mutations in the leptin gene

Congenital leptin deficiency is a rare autosomal recessive monogenic obesity syndrome caused by mutations in the leptin gene. This review describes the molecular and cellular characteristics of the eight distinct mutations found so far in humans.

Detalles Bibliográficos
Autores principales: Funcke, Jan-Bernd, von Schnurbein, Julia, Lennerz, Belinda, Lahr, Georgia, Debatin, Klaus-Michael, Fischer-Posovszky, Pamela, Wabitsch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644131/
https://www.ncbi.nlm.nih.gov/pubmed/26567097
http://dx.doi.org/10.1186/s40348-014-0003-1