Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function

Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate level of function to permit robust single-cell contr...

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Detalles Bibliográficos
Autores principales: Birket, Matthew J., Ribeiro, Marcelo C., Kosmidis, Georgios, Ward, Dorien, Leitoguinho, Ana Rita, van de Pol, Vera, Dambrot, Cheryl, Devalla, Harsha D., Davis, Richard P., Mastroberardino, Pier G., Atsma, Douwe E., Passier, Robert, Mummery, Christine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644234/
https://www.ncbi.nlm.nih.gov/pubmed/26489474
http://dx.doi.org/10.1016/j.celrep.2015.09.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644234/
https://www.ncbi.nlm.nih.gov/pubmed/26489474
http://dx.doi.org/10.1016/j.celrep.2015.09.025

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