Unmasking Determinants of Specificity in the Human Kinome

Protein kinases control cellular responses to environmental cues by swift and accurate signal processing. Breakdowns in this high-fidelity capability are a driving force in cancer and other diseases. Thus, our limited understanding of which amino acids in the kinase domain encode substrate specifici...

Descripción completa

Detalles Bibliográficos
Autores principales: Creixell, Pau, Palmeri, Antonio, Miller, Chad J., Lou, Hua Jane, Santini, Cristina C., Nielsen, Morten, Turk, Benjamin E., Linding, Rune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Theory
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644237/
https://www.ncbi.nlm.nih.gov/pubmed/26388442
http://dx.doi.org/10.1016/j.cell.2015.08.057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644237/
https://www.ncbi.nlm.nih.gov/pubmed/26388442
http://dx.doi.org/10.1016/j.cell.2015.08.057

Ejemplares similares