Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

INTRODUCTION: Transgenic overexpression of amyloid precursor protein (APP) genes that are either entirely human in sequence or have humanized Aβ sequences can produce Alzheimer-type amyloidosis in mice, provided the transgenes also encode mutations linked to familial Alzheimer’s Disease (FAD). Altho...

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Detalles Bibliográficos
Autores principales: Xu, Guilian, Ran, Yong, Fromholt, Susan E., Fu, Chunhua, Yachnis, Anthony T., Golde, Todd E., Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644287/
https://www.ncbi.nlm.nih.gov/pubmed/26566997
http://dx.doi.org/10.1186/s40478-015-0252-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644287/
https://www.ncbi.nlm.nih.gov/pubmed/26566997
http://dx.doi.org/10.1186/s40478-015-0252-9

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