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Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

INTRODUCTION: Transgenic overexpression of amyloid precursor protein (APP) genes that are either entirely human in sequence or have humanized Aβ sequences can produce Alzheimer-type amyloidosis in mice, provided the transgenes also encode mutations linked to familial Alzheimer’s Disease (FAD). Altho...

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Detalles Bibliográficos
Autores principales:	Xu, Guilian, Ran, Yong, Fromholt, Susan E., Fu, Chunhua, Yachnis, Anthony T., Golde, Todd E., Borchelt, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644287/ https://www.ncbi.nlm.nih.gov/pubmed/26566997 http://dx.doi.org/10.1186/s40478-015-0252-9

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