Differential PAX5 levels promote malignant B cell infiltration, progression and drug resistance and predict a poor prognosis in MCL patients independent of CCND1

Reduced PAX5 levels play important roles in the pathogenesis of human B-cell acute lymphoblastic leukemia. However, the role of PAX5 in human lymphoma remains unclear. We generated PAX5-silenced cells using mantle cell lymphoma (MCL) as a model system. These PAX5(−) MCL cells exhibited unexpected ph...

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Detalles Bibliográficos
Autores principales: Teo, Albert E., Chen, Zheng, Miranda, Roberto N., McDonnell, Timothy, Medeiros, L. Jeffrey, McCarty, Nami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644730/
https://www.ncbi.nlm.nih.gov/pubmed/26073757
http://dx.doi.org/10.1038/leu.2015.140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644730/
https://www.ncbi.nlm.nih.gov/pubmed/26073757
http://dx.doi.org/10.1038/leu.2015.140

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