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Differential PAX5 levels promote malignant B cell infiltration, progression and drug resistance and predict a poor prognosis in MCL patients independent of CCND1

Reduced PAX5 levels play important roles in the pathogenesis of human B-cell acute lymphoblastic leukemia. However, the role of PAX5 in human lymphoma remains unclear. We generated PAX5-silenced cells using mantle cell lymphoma (MCL) as a model system. These PAX5(−) MCL cells exhibited unexpected ph...

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Detalles Bibliográficos
Autores principales:	Teo, Albert E., Chen, Zheng, Miranda, Roberto N., McDonnell, Timothy, Medeiros, L. Jeffrey, McCarty, Nami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644730/ https://www.ncbi.nlm.nih.gov/pubmed/26073757 http://dx.doi.org/10.1038/leu.2015.140

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