Tetrathiomolybdate mediates cisplatin-induced p38 signaling and EGFR degradation and enhances response to cisplatin therapy in gynecologic cancers

Cisplatin and its analogs are among the most widely used chemotherapeutic agents against various types of cancer. It is known that cisplatin can activate epidermal growth factor receptor (EGFR), which may provide a survival benefit in cancers. Tetrathiomolybdate (TM) is a potent anti-cancer and anti...

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Detalles Bibliográficos
Autores principales: Kim, Kyu Kwang, Han, Alex, Yano, Naohiro, Ribeiro, Jennifer R., Lokich, Elizabeth, Singh, Rakesh K., Moore, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644948/
https://www.ncbi.nlm.nih.gov/pubmed/26568478
http://dx.doi.org/10.1038/srep15911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644948/
https://www.ncbi.nlm.nih.gov/pubmed/26568478
http://dx.doi.org/10.1038/srep15911

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