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Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations
Network models are a well established tool for studying the robustness of complex systems, including modelling the effect of loss of function mutations in protein interaction networks. Past work has concentrated on average damage caused by random node removal, with little attention to the shape of t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644955/ https://www.ncbi.nlm.nih.gov/pubmed/26568486 http://dx.doi.org/10.1038/srep16726 |
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author | Lehtinen, Sonja Bähler, Jürg Orengo, Christine |
author_facet | Lehtinen, Sonja Bähler, Jürg Orengo, Christine |
author_sort | Lehtinen, Sonja |
collection | PubMed |
description | Network models are a well established tool for studying the robustness of complex systems, including modelling the effect of loss of function mutations in protein interaction networks. Past work has concentrated on average damage caused by random node removal, with little attention to the shape of the damage distribution. In this work, we use fission yeast co-expression networks before and after exposure to stress to model the effect of stress on mutational robustness. We find that exposure to stress decreases the average damage from node removal, suggesting stress induces greater tolerance to loss of function mutations. The shape of the damage distribution is also changed upon stress, with a greater incidence of extreme damage after exposure to stress. We demonstrate that the change in shape of the damage distribution can have considerable functional consequences, highlighting the need to consider the damage distribution in addition to average behaviour. |
format | Online Article Text |
id | pubmed-4644955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46449552015-11-20 Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations Lehtinen, Sonja Bähler, Jürg Orengo, Christine Sci Rep Article Network models are a well established tool for studying the robustness of complex systems, including modelling the effect of loss of function mutations in protein interaction networks. Past work has concentrated on average damage caused by random node removal, with little attention to the shape of the damage distribution. In this work, we use fission yeast co-expression networks before and after exposure to stress to model the effect of stress on mutational robustness. We find that exposure to stress decreases the average damage from node removal, suggesting stress induces greater tolerance to loss of function mutations. The shape of the damage distribution is also changed upon stress, with a greater incidence of extreme damage after exposure to stress. We demonstrate that the change in shape of the damage distribution can have considerable functional consequences, highlighting the need to consider the damage distribution in addition to average behaviour. Nature Publishing Group 2015-11-16 /pmc/articles/PMC4644955/ /pubmed/26568486 http://dx.doi.org/10.1038/srep16726 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lehtinen, Sonja Bähler, Jürg Orengo, Christine Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations |
title | Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations |
title_full | Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations |
title_fullStr | Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations |
title_full_unstemmed | Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations |
title_short | Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations |
title_sort | co-expression network models suggest that stress increases tolerance to mutations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644955/ https://www.ncbi.nlm.nih.gov/pubmed/26568486 http://dx.doi.org/10.1038/srep16726 |
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