Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer

AZD6244 (ARRY-142886), a highly selective MAPK-ERK kinase inhibitor, has shown excellent clinical efficacy in many tumors. However, the anti-tumor and anti-angiogenesis efficacy of AZD6244 on gastric cancer has not been well characterized. In this study, high p-ERK expression was associated with adv...

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Detalles Bibliográficos
Autores principales: Gao, Jin-Hang, Wang, Chun-Hui, Tong, Huan, Wen, Shi-Lei, Huang, Zhi-Yin, Tang, Cheng-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644956/
https://www.ncbi.nlm.nih.gov/pubmed/26567773
http://dx.doi.org/10.1038/srep16382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644956/
https://www.ncbi.nlm.nih.gov/pubmed/26567773
http://dx.doi.org/10.1038/srep16382

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