Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro­benzamido)-2-hy­droxy­prop­yl]deca­hydro­isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro­benzoyl)pyrrolidin-2-yl]-2-hy­droxy­eth­yl}deca­hydro­iso­quinoline-3-carboxamide

The crystal structure and absolute configuration of the two new title nelfinavir analogs, C(24)H(35)ClN(4)O(5), (I), and C(27)H(39)ClN(4)O(5), (II), have been determined. Each of these mol­ecules exhibits a number of disordered moieties. There are intra­molecular N—H⋯O hydrogen bonds in both (I) and...

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Detalles Bibliográficos
Autores principales: Maxson, Tucker, Bertke, Jeffery A., Gray, Danielle L., Mitchell, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645022/
https://www.ncbi.nlm.nih.gov/pubmed/26594520
http://dx.doi.org/10.1107/S2056989015020046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645022/
https://www.ncbi.nlm.nih.gov/pubmed/26594520
http://dx.doi.org/10.1107/S2056989015020046

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