Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Bile acids can regulate nutrient metabolism through the activation of the cell membrane receptor GPBAR1 and the nuclear receptor FXR. Developing an exogenous control over these receptors represents an attractive strategy for the treatment of enterohepatic and metabolic disorders. A number of dual GP...

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Detalles Bibliográficos
Autores principales: Di Leva, Francesco Saverio, Festa, Carmen, Renga, Barbara, Sepe, Valentina, Novellino, Ettore, Fiorucci, Stefano, Zampella, Angela, Limongelli, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645117/
https://www.ncbi.nlm.nih.gov/pubmed/26567894
http://dx.doi.org/10.1038/srep16605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645117/
https://www.ncbi.nlm.nih.gov/pubmed/26567894
http://dx.doi.org/10.1038/srep16605

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