Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor

Entry inhibitors represent a potent class of antiretroviral drugs that target a host cell protein, CCR5, an HIV-1 entry coreceptor, and not viral protein. Lack of sensitivity can occur due to preexisting virus that uses the CXCR4 coreceptor, while true resistance occurs through viral adaptation to u...

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Detalles Bibliográficos
Autores principales: Jiang, Xiaowei, Feyertag, Felix, Meehan, Conor J., McCormack, Grace P., Travers, Simon A., Craig, Charles, Westby, Mike, Lewis, Marilyn, Robertson, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645647/
https://www.ncbi.nlm.nih.gov/pubmed/26339063
http://dx.doi.org/10.1128/JVI.01384-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645647/
https://www.ncbi.nlm.nih.gov/pubmed/26339063
http://dx.doi.org/10.1128/JVI.01384-15

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