Cargando…

Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor

Entry inhibitors represent a potent class of antiretroviral drugs that target a host cell protein, CCR5, an HIV-1 entry coreceptor, and not viral protein. Lack of sensitivity can occur due to preexisting virus that uses the CXCR4 coreceptor, while true resistance occurs through viral adaptation to u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Xiaowei, Feyertag, Felix, Meehan, Conor J., McCormack, Grace P., Travers, Simon A., Craig, Charles, Westby, Mike, Lewis, Marilyn, Robertson, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2015
Materias:	Genetic Diversity and Evolution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645647/ https://www.ncbi.nlm.nih.gov/pubmed/26339063 http://dx.doi.org/10.1128/JVI.01384-15

Ejemplares similares

Incidence of CXCR4 tropism and CCR5-tropic resistance in treatment-experienced participants receiving maraviroc in the 48-week MOTIVATE 1 and 2 trials
por: Jubb, Becky, et al.
Publicado: (2019)

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry
por: Roche, Michael, et al.
Publicado: (2011)

Deep Sequencing of Norovirus Genomes Defines Evolutionary Patterns in an Urban Tropical Setting
por: Cotten, Matthew, et al.
Publicado: (2014)

Characterization of Clade 7.2 H5 Avian Influenza Viruses That Continue To Circulate in Chickens in China
por: Liu, Liling, et al.
Publicado: (2016)

Stability of the Parainfluenza Virus 5 Genome Revealed by Deep Sequencing of Strains Isolated from Different Hosts and following Passage in Cell Culture
por: Rima, Bert K., et al.
Publicado: (2014)

Endocytosis and Recycling of the HIV Coreceptor Ccr5
por: Signoret, Nathalie, et al.
Publicado: (2000)

Pharmacokinetics, Safety and Efficacy of Maraviroc in Treatment-experienced Pediatric Patients Infected With CCR5-Tropic HIV-1
por: Giaquinto, Carlo, et al.
Publicado: (2018)

Evolution of coreceptor utilization to escape CCR5 antagonist therapy
por: Zhang, Jie, et al.
Publicado: (2016)

Maraviroc – A CCR5 Antagonist for the Treatment of HIV-1 Infection
por: Van Der Ryst, Elna
Publicado: (2015)

Unfixed Endogenous Retroviral Insertions in the Human Population
por: Marchi, Emanuele, et al.
Publicado: (2014)

Powerful Sequence Similarity Search Methods and In-Depth Manual Analyses Can Identify Remote Homologs in Many Apparently “Orphan” Viral Proteins
por: Kuchibhatla, Durga B., et al.
Publicado: (2014)

Genome Diversity of Epstein-Barr Virus from Multiple Tumor Types and Normal Infection
por: Palser, Anne L., et al.
Publicado: (2015)

Local Evolutionary Patterns of Human Respiratory Syncytial Virus Derived from Whole-Genome Sequencing
por: Agoti, Charles N., et al.
Publicado: (2015)

Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam
por: Geoghegan, Jemma L., et al.
Publicado: (2015)

Sinorhizobium meliloti Phage ΦM9 Defines a New Group of T4 Superfamily Phages with Unusual Genomic Features but a Common T=16 Capsid
por: Johnson, Matthew C., et al.
Publicado: (2015)

Novel Denisovan and Neanderthal Retroviruses
por: Lee, Adam, et al.
Publicado: (2014)

Accumulation of Human-Adapting Mutations during Circulation of A(H1N1)pdm09 Influenza Virus in Humans in the United Kingdom
por: Elderfield, Ruth A., et al.
Publicado: (2014)

Evolution of Cocirculating Varicella-Zoster Virus Genotypes during a Chickenpox Outbreak in Guinea-Bissau
por: Depledge, Daniel P., et al.
Publicado: (2014)

Molecular Evolutionary Dynamics of Respiratory Syncytial Virus Group A in Recurrent Epidemics in Coastal Kenya
por: Otieno, James R., et al.
Publicado: (2016)

Increasing Clinical Severity during a Dengue Virus Type 3 Cuban Epidemic: Deep Sequencing of Evolving Viral Populations
por: Rodriguez-Roche, Rosmari, et al.
Publicado: (2016)

Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro
por: Murrell, Isa, et al.
Publicado: (2016)

Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae
por: Gjessing, Mona C., et al.
Publicado: (2015)

Molecular Epidemiology and Evolution of Influenza Viruses Circulating within European Swine between 2009 and 2013
por: Watson, Simon J., et al.
Publicado: (2015)

Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification
por: Li, Hui, et al.
Publicado: (2015)

Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China
por: Liang, Libin, et al.
Publicado: (2016)

Spatial-Temporal Patterns of Viral Amplification and Interference Initiated by a Single Infected Cell
por: Akpinar, Fulya, et al.
Publicado: (2016)

Successive Respiratory Syncytial Virus Epidemics in Local Populations Arise from Multiple Variant Introductions, Providing Insights into Virus Persistence
por: Agoti, Charles N., et al.
Publicado: (2015)

Characterization of a Novel Hepadnavirus in the White Sucker (Catostomus commersonii) from the Great Lakes Region of the United States
por: Hahn, Cassidy M., et al.
Publicado: (2015)

Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus Flavivirus
por: Alkan, Cigdem, et al.
Publicado: (2015)

Complete Unique Genome Sequence, Expression Profile, and Salivary Gland Tissue Tropism of the Herpesvirus 7 Homolog in Pigtailed Macaques
por: Staheli, Jeannette P., et al.
Publicado: (2016)

Time-Dependent Rate Phenomenon in Viruses
por: Aiewsakun, Pakorn, et al.
Publicado: (2016)

Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification
por: Sobel Leonard, Ashley, et al.
Publicado: (2016)

Evidence for the Introduction, Reassortment, and Persistence of Diverse Influenza A Viruses in Antarctica
por: Hurt, Aeron C., et al.
Publicado: (2016)

Characterization of Equine Infectious Anemia Virus Long Terminal Repeat Quasispecies In Vitro and In Vivo
por: Wang, Xue-Feng, et al.
Publicado: (2018)

Weaker HLA Footprints on HIV in the Unique and Highly Genetically Admixed Host Population of Mexico
por: Soto-Nava, Maribel, et al.
Publicado: (2018)

Heterogeneity of the Epstein-Barr Virus (EBV) Major Internal Repeat Reveals Evolutionary Mechanisms of EBV and a Functional Defect in the Prototype EBV Strain B95-8
por: Ba abdullah, Mohammed M., et al.
Publicado: (2017)

Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants
por: Chen, Zigui, et al.
Publicado: (2017)

Avian Influenza Viruses in Wild Birds: Virus Evolution in a Multihost Ecosystem
por: Venkatesh, Divya, et al.
Publicado: (2018)

Insights into Circovirus Host Range from the Genomic Fossil Record
por: Dennis, Tristan P. W., et al.
Publicado: (2018)

A Novel Marsupial Hepatitis A Virus Corroborates Complex Evolutionary Patterns Shaping the Genus Hepatovirus
por: de Oliveira Carneiro, Ianei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6di0pmid3tshm39vvnp85c0ia3