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All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation

Retinoic acid (RA) is an important biological signal that directly differentiates cells during embryonic development and tumorigenesis. However, the molecular mechanism of RA-mediated differentiation in hepatic cancer stem cells (hCSCs) is not well understood. In this study, we found that mRNA expre...

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Detalles Bibliográficos
Autores principales: Zhu, Xinfeng, Wang, Wenxue, Zhang, Xia, Bai, Jianhua, Chen, Gang, Li, Li, Li, Meizhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646487/
https://www.ncbi.nlm.nih.gov/pubmed/26571119
http://dx.doi.org/10.1371/journal.pone.0143255