High-Throughput Amplicon-Based Copy Number Detection of 11 Genes in Formalin-Fixed Paraffin-Embedded Ovarian Tumour Samples by MLPA-Seq

Whilst next generation sequencing can report point mutations in fixed tissue tumour samples reliably, the accurate determination of copy number is more challenging. The conventional Multiplex Ligation-dependent Probe Amplification (MLPA) assay is an effective tool for measurement of gene dosage, but...

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Detalles Bibliográficos
Autores principales: Kondrashova, Olga, Love, Clare J., Lunke, Sebastian, Hsu, Arthur L., Waring, Paul M., Taylor, Graham R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646639/
https://www.ncbi.nlm.nih.gov/pubmed/26569395
http://dx.doi.org/10.1371/journal.pone.0143006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646639/
https://www.ncbi.nlm.nih.gov/pubmed/26569395
http://dx.doi.org/10.1371/journal.pone.0143006

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