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Structure of transcribed chromatin is a sensor of DNA damage

Early detection and repair of damaged DNA is essential for cell functioning and survival. Although multiple cellular systems are involved in the repair of single-strand DNA breaks (SSBs), it remains unknown how SSBs present in the nontemplate strand (NT-SSBs) of DNA organized in chromatin are detect...

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Detalles Bibliográficos
Autores principales: Pestov, Nikolay A., Gerasimova, Nadezhda S., Kulaeva, Olga I., Studitsky, Vasily M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646769/
https://www.ncbi.nlm.nih.gov/pubmed/26601207
http://dx.doi.org/10.1126/sciadv.1500021