MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs

The RNA polymerase II mediator complex subunit 12 (MED12) is frequently mutated in human cancers, and loss of MED12 has been shown to induce drug resistance through activation of transforming growth factor–β receptor (TGF-βR) signaling. We identified MED12 as a substrate for coactivator-associated a...

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Detalles Bibliográficos
Autores principales: Wang, Lu, Zeng, Hao, Wang, Qiang, Zhao, Zibo, Boyer, Thomas G., Bian, Xiuwu, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646802/
https://www.ncbi.nlm.nih.gov/pubmed/26601288
http://dx.doi.org/10.1126/sciadv.1500463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646802/
https://www.ncbi.nlm.nih.gov/pubmed/26601288
http://dx.doi.org/10.1126/sciadv.1500463

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