Identification of a novel cis-regulatory element essential for immune tolerance

Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tol...

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Detalles Bibliográficos
Autores principales: LaFlam, Taylor N., Seumois, Grégory, Miller, Corey N., Lwin, Wint, Fasano, Kayla J., Waterfield, Michael, Proekt, Irina, Vijayanand, Pandurangan, Anderson, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647269/
https://www.ncbi.nlm.nih.gov/pubmed/26527800
http://dx.doi.org/10.1084/jem.20151069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647269/
https://www.ncbi.nlm.nih.gov/pubmed/26527800
http://dx.doi.org/10.1084/jem.20151069

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