A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality

BACKGROUND: Target selection for oncology is a crucial step in the successful development of therapeutics. Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 editing of specific loci offers an alternative method to RNA interference and small molecule inhibitors for determining w...

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Detalles Bibliográficos
Autores principales: Grassian, A. R., Scales, T. M. E., Knutson, S. K., Kuntz, K. W., McCarthy, N. J., Lowe, C. E., Moore, J. D., Copeland, R. A., Keilhack, H., Smith, J. J., Wickenden, J. A., Ribich, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647477/
https://www.ncbi.nlm.nih.gov/pubmed/26578851
http://dx.doi.org/10.1186/s12575-015-0028-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647477/
https://www.ncbi.nlm.nih.gov/pubmed/26578851
http://dx.doi.org/10.1186/s12575-015-0028-4

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