Quantitative framework for ordered degradation of APC/C substrates

BACKGROUND: During cell-cycle progression, substrates of a single master regulatory enzyme can be modified in a specific order. Here, we used experimental and computational approaches to dissect the quantitative mechanisms underlying the ordered degradation of the substrates of the ubiquitin ligase...

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Detalles Bibliográficos
Autores principales: Lu, Dan, Girard, Juliet R., Li, Weihan, Mizrak, Arda, Morgan, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647693/
https://www.ncbi.nlm.nih.gov/pubmed/26573515
http://dx.doi.org/10.1186/s12915-015-0205-6