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Calcium-controlled conformational choreography in the N-terminal half of adseverin

Adseverin is a member of the calcium-regulated gelsolin superfamily of actin-binding proteins. Here we report the crystal structure of the calcium-free N-terminal half of adseverin (iA1–A3) and the Ca(2+)-bound structure of A3, which reveal structural similarities and differences with gelsolin. Solu...

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Detalles Bibliográficos
Autores principales: Chumnarnsilpa, Sakesit, Robinson, Robert C., Grimes, Jonathan M., Leyrat, Cedric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647846/
https://www.ncbi.nlm.nih.gov/pubmed/26365202
http://dx.doi.org/10.1038/ncomms9254