Characterization of the relationship between dose and blood eosinophil response following subcutaneous administration of mepolizumab

Objective: Mepolizumab is a humanized IgG1 monoclonal antibody that blocks human IL-5 from binding to the IL-5 receptor, which is mainly expressed on eosinophils. Eosinophils are key cells in the inflammatory cascade of various diseases, including asthma. This study investigated the pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Pouliquen, Isabelle J., Kornmann, Oliver, Barton, Sharon V., Price, Jeffrey A., Ortega, Hector G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dustri-Verlag Dr. Karl Feistle 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647865/
https://www.ncbi.nlm.nih.gov/pubmed/26445140
http://dx.doi.org/10.5414/CP202446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647865/
https://www.ncbi.nlm.nih.gov/pubmed/26445140
http://dx.doi.org/10.5414/CP202446

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