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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
BACKGROUND: To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. METHODS: We created a genetic score combining the effects of alleles of...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
The Lancet, Diabetes & Endocrinology
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648058/ https://www.ncbi.nlm.nih.gov/pubmed/25726324 http://dx.doi.org/10.1016/S2213-8587(15)00034-0 |