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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis

BACKGROUND: To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. METHODS: We created a genetic score combining the effects of alleles of...

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Detalles Bibliográficos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Lancet, Diabetes & Endocrinology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648058/ https://www.ncbi.nlm.nih.gov/pubmed/25726324 http://dx.doi.org/10.1016/S2213-8587(15)00034-0

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