A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase

As a critical regulator of the B-cell receptor signaling pathway, Bruton’s tyrosine kinase (Btk) has attracted intensive drug discovery efforts for treating B-cell lineage cancers and autoimmune disorders. In particular, covalent inhibitors targeting Cys481 in Btk have demonstrated impressive clinic...

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Detalles Bibliográficos
Autores principales: Zuo, Yingying, Shi, Yanxia, Li, Xitao, Teng, Yingqi, Pan, Zhengying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648318/
https://www.ncbi.nlm.nih.gov/pubmed/26531233
http://dx.doi.org/10.1038/srep16136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648318/
https://www.ncbi.nlm.nih.gov/pubmed/26531233
http://dx.doi.org/10.1038/srep16136

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