Cumulus Cells Block Oocyte Meiotic Resumption via Gap Junctions in Cumulus Oocyte Complexes Subjected to DNA Double-Strand Breaks

During mammalian oocyte growth, genomic DNA may accumulate DNA double-strand breaks (DSBs) induced by factors such as reactive oxygen species. Recent evidence demonstrated that slight DSBs do not activate DNA damage checkpoint proteins in denuded oocytes. These oocytes, even with DNA DSBs, can resum...

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Detalles Bibliográficos
Autores principales: Sun, Ming-Hong, Zheng, Jie, Xie, Feng-Yun, Shen, Wei, Yin, Shen, Ma, Jun-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648486/
https://www.ncbi.nlm.nih.gov/pubmed/26575642
http://dx.doi.org/10.1371/journal.pone.0143223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648486/
https://www.ncbi.nlm.nih.gov/pubmed/26575642
http://dx.doi.org/10.1371/journal.pone.0143223

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