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Beyond the E-Value: Stratified Statistics for Protein Domain Prediction

E-values have been the dominant statistic for protein sequence analysis for the past two decades: from identifying statistically significant local sequence alignments to evaluating matches to hidden Markov models describing protein domain families. Here we formally show that for “stratified” multipl...

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Detalles Bibliográficos
Autores principales: Ochoa, Alejandro, Storey, John D., Llinás, Manuel, Singh, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648515/
https://www.ncbi.nlm.nih.gov/pubmed/26575353
http://dx.doi.org/10.1371/journal.pcbi.1004509