Five-aza-2′-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells

DNA methyltransferase inhibitors (DNMT inhibitors) are administered for high-risk MDS, but their action mechanisms are not fully understood. Hence, we performed a genome-wide DNA methylation assay and focused on cholesterol 25-hydroxylase (CH25H) among the genes whose expression was up-regulated and...

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Detalles Bibliográficos
Autores principales: Tsujioka, Takayuki, Yokoi, Akira, Itano, Yoshitaro, Takahashi, Kentaro, Ouchida, Mamoru, Okamoto, Shuichiro, Kondo, Toshinori, Suemori, Shin-ichiro, Tohyama, Yumi, Tohyama, Kaoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649363/
https://www.ncbi.nlm.nih.gov/pubmed/26577244
http://dx.doi.org/10.1038/srep16709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649363/
https://www.ncbi.nlm.nih.gov/pubmed/26577244
http://dx.doi.org/10.1038/srep16709

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