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Structural basis of Sorcin-mediated calcium-dependent signal transduction

Sorcin is an essential penta-EF hand calcium binding protein, able to confer the multi-drug resistance phenotype to drug-sensitive cancer cells and to reduce Endoplasmic Reticulum stress and cell death. Sorcin silencing blocks cell cycle progression in mitosis and induces cell death by triggering ap...

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Detalles Bibliográficos
Autores principales: Ilari, Andrea, Fiorillo, Annarita, Poser, Elena, Lalioti, Vasiliki S., Sundell, Gustav N., Ivarsson, Ylva, Genovese, Ilaria, Colotti, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649501/
https://www.ncbi.nlm.nih.gov/pubmed/26577048
http://dx.doi.org/10.1038/srep16828