TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

Different molecular subtypes of glioblastoma (GBM) have been recently identified, of which the mesenchymal subtype is associated with worst prognoses. Here, we report that transforming growth factor-β (TGF-β) is able to induce a mesenchymal phenotype in GBM that involves activation of SMAD2 and ZEB1...

Descripción completa

Detalles Bibliográficos
Autores principales: Joseph, J V, Conroy, S, Tomar, T, Eggens-Meijer, E, Bhat, K, Copray, S, Walenkamp, A M E, Boddeke, E, Balasubramanyian, V, Wagemakers, M, den Dunnen, W F A, Kruyt, F A E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649508/
https://www.ncbi.nlm.nih.gov/pubmed/25275602
http://dx.doi.org/10.1038/cddis.2014.395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649508/
https://www.ncbi.nlm.nih.gov/pubmed/25275602
http://dx.doi.org/10.1038/cddis.2014.395

Ejemplares similares